The hotel is close to many popular sites in the city. Those who are staying at the Grand Hotel Don Gregorio will be able to visit Saint Stephen's Convent as well as Plaza Mayor. They are only a short walk from a number of cathedrals as well as many places where they can dine and shop. Many of the attractions are only a short walk from the Grand Hotel Don Gregorio. Those who choose to stay at the hotel will also be able to use public transportation that can help them to reach other areas in and around the city that they want to visit.

The rooms at the Grand Hotel Don Gregorio have modern amenities and old world charm. Some of the amenities that guests can find at the hotels include a private Jacuzzi, private bathrooms, bathrobes, access to the Internet, and phones.

The hotel is located in what was once a palace. Those who stay at the Grand Hotel Don Gregorio will be able to dine at the onsite restaurant, which serves traditional cuisine.